3 There are two issues to be considered with regard to insulin. HOMA-IR is calculated based on the measurement of fasting glucose and insulin levels. Several surrogate markers have therefore been proposed, including the homeostatic model assessment of IR (HOMA-IR), one of the most widely used. 2 Hyperinsulinemic–euglycemic clamp is the direct method to measure IR and is considered the “gold standard” procedure, but it is difficult to perform in daily practice. The evaluation of IR requires sophisticated methods which are not available for use in daily clinical practice. 1 IR predisposes to several metabolic disorders including hyperglycemia, high blood pressure, and dyslipidemia, all of them strongly associated with diabetes, atherosclerosis, and cardiovascular disease. Insulin resistance (IR) involves decreased cell sensitivity to insulin and is a central characteristic of metabolic syndrome (MS). La simplicidad de su cálculo justifica profundizar su estudio como marcador alternativo de insulinorresistencia. ConclusionesĮl índice TyG fue un buen discriminante de SM. El punto de corte para el índice TyG en hombres fue 8,8 y en mujeres 8,7 los valores respectivos para TG/C-HDL fueron 3,1 en hombres y 2,2 en mujeres. Las razones de probabilidad y probabilidades postest positivas para dichos parámetros fueron 5,8 vs. Los puntos de corte para SM en la población total fueron: 8,8 para el índice TyG (sensibilidad = 79%, especificidad = 86%), y 2,4 para la relación TG/C-HDL (sensibilidad = 88%, especificidad = 72%). ResultadosĮl valor medio del índice TyG fue mayor en el grupo con SM comparado con el grupo sin SM y fue buena su correlación con TG/C-HDL. Se evaluaron las capacidades discriminativas para SM del índice TyG, calculado como Ln (TG x glucosa /2), y de la relación TG/C-HDL. Se realizó un estudio observacional, transversal, en 525 individuos adultos de una población de Bahía Blanca, Argentina, quienes fueron divididos en dos grupos: con SM (n = 89) y sin SM (n = 436). El objetivo de este estudio fue evaluar el índice triglicéridos y glucosa (TyG) como marcador de insulinorresistencia y compararlo con la relación triglicéridos y colesterol-HDL (TG/C-HDL), en individuos con y sin síndrome metabólico (SM). Por lo cual se han sugerido distintos estimadores de esta condición. La evaluación de la insulinorresistencia requiere de metodología sofisticada de difícil aplicación. Its simple calculation warrants its further study as an alternative marker of insulin resistance. The TyG index was a good discriminant of MS. The cut-off point for the TyG index was 8.8 in men and 8.7 in women the respective values for TG/C-HDL were 3.1 in men and 2.2 in women. The positive likelihood ratios and post-test probabilities for these parameters were 5.8 vs 3.1 and 72% vs 58% respectively. ![]() The cut-off values for MS in the overall population were 8.8 for the TyG index (sensitivity = 79%, specificity = 86%), and 2.4 for the TG/HDL-C ratio (sensitivity = 88%, specificity = 72%). The mean value of the TyG index was higher in the group with MS as compared to the group without MS and its correlation with the TG/HDL-C ratio was good. The discriminating capacities for MS of the TyG index, calculated as Ln (TG × glucose /2), and the TG/HDL-C ratio were evaluated. Materials and methodsĪn observational, cross-sectional study was conducted on 525 adults of a population from Bahia Blanca, Argentina, who were divided into two groups: with MS (n = 89) and without MS (n = 436). The aim of this study was to evaluate the triglycerides and glucose (TyG) index as a marker of insulin resistance and to compare it to the triglycerides/HDL cholesterol ratio (TG/HDL-C), in subjects with and without metabolic syndrome (MS). Therefore, different estimators for this condition have been suggested. Insulin resistance assessment requires sophisticated methodology of difficult application.
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